Read more at: A new method for prediction of amorphous drug stability
A new method for prediction of amorphous drug stability
1 April 2014
A new method for measuring of molecular mobility in glassy materials has been developed using terahertz spectroscopy. The absorption level of amorphous drugs at terahertz frequencies below Tg correlates with the stability of the drug as an amorphous solid. The molecular mobility responsible for the glass crystallisation significantly decreases at around a universal value of 0.67 Tg. This explains why the commonly used rules of thumb for glasses to remain stable below 0.8 Tg or Tg – 20 K do not work reliably.