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New paper: Crystallisation and phase changes from amorphous paracetamol

last modified May 23, 2014 02:26 PM
We used terahertz spectroscopy to investigate the crystallisation and phase changes in paracetamol from the amorphous solid to the liquid phase

 

This study evolved from Juraj's previous work on the characterisation of amorphous materials using terahertz spectroscopy, published last year in PCCP. Together with Michael and Miriam, who worked in our group as part of their final year IIB undergraduate research project, we were able to apply this method to accurately determine the onset of crystallisation in a sample of paracetamol by investigating the inter-molecular hydrogen bonding dynamics during this process.

J. Sibik, M.J. Sargent, M. Franklin, and J.A. Zeitler, Crystallisation and phase changes in paracetamol from the amorphous solid to the liquid phase, Molecular Pharmaceutics, doi:10.1021/mp400768m, 11, 1326–1334  (2014). oalogo.jpg

J. Sibik, E.Y. Shalaev and J.A. Zeitler, Glassy dynamics of sorbitol solutions at terahertz frequencies, Physical Chemistry Chemical Physicsdoi:10.1039/C3CP51936H, 15, 11931-11942 (2013). oalogo.jpg

This work was funded by the UK Engineering and Physical Sciences Research Council (EPSRC).

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